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The School of Medicine is pleased to announce the recipients of the Discovery Fund Synergy Awards (DFSA) Program. These awards are designed to spark new, synergistic interactions between investigators and potentiate scientific achievements of the highest quality and impact. The following projects were awarded in the range of $100,000 each.

Discovery Fund Synergy Awards
July 1, 2014

Boyd, Cynthia
   Jennifer Wolff
   Hadi Kharrazi
   Bruce Leff
Medicine, Geriatric Medicine and Gerontology
Health Policy and Management JHU
Health Policy and Management, JHSPH
Addressing medication regimen complexity in skilled home health care
Caterina, Michael
   Mollie Meffert
Neurosurgery, Biological Chemistry
Biological Chemistry
Contributions of the Lin28/let-7 axis to neuropathic pain
Cormack, Brendan
   William Bishai
Molecular Biology and Genetics
Medicine, ID, TB Center
How does Pyrazinamide, a key drug for the treatment of TB, work?
Durand, Christine
   Dorry Segev
   Aaron Tobian
   Andrew Redd
Medicine, ID
Defining the epidemiology and feasibility of the HIV-infected deceased donor organ pool
George, Richard
   Rajat Mittal
   Jung-Hee Seo
Mechanical Engineering
Mechanical Engineering
A new paradigm for the development of clinically applicable diagnostic tools via imaging-based computational fluid dynamic modeling --- Prediction of left ventricular thrombus
Halushka, Marc
   Akhilesh Pandey
   Kenneth Witwer
   Andrea Zachary
IGM, Biological Chemistry
Molecular & Comparative Pathobiology
Medicine, Immunogenetics & Transplantation Immunology
v2.0 miRNA biomarker discovery for improved diagnostics
Linden, David
   Gregory Ball
Psychological and Brain Sciences, JHU Krieger
Modulation of synapses by estrogen examined with subcellular resolution in the intact brain
Liu, Jun
   Martin Pomper
Pharmacology and Molecular Sciences
Design, synthesis and characterization of glucose-triptolide conjugates as novel tumor-targeted anticancer agents
Potter, Christopher
   Marcelo Jacobs-Lorena
Molecular Microbiology Immunology, JHSPH
Imaging sensory activity in the Anopheles gambiae mosquito brain
Sfanos, Karen
   Angelo De Marzo
   Srinivasan Yegnasubramanian
Metagenomic studies of microorganisms in benign prostatic hyperplasia
Shafi, Tariq
   Harry Silber
   Joseph Coresh
Medicine, Nephrology
Medicine, Cardiology
Epidemiology, Medicine, Biostatistics, JHSPH, SOM
Left ventricular end diastolic pressure-guided volume management in dialysis patients
Soloski, Mark
   John Aucott
   Kathleen Kortte
   Martin Pomper
Medicine, Rheumatology
Medicine, Rheumatology
Physical Medicine and Rehabilitation
A multidisciplinary approach toward Lyme Borreliosis
Wu, Mark
   George Capone
   Abhay Moghekar
   Adam Spira
Neurology, Medicine
Mental Health, JHSPH, Psychiatry, SOM
Sleep-disordered breathing and beta-amyloid in Down Syndrome
Xiao, Jie
   Xin Chen
Biophysics and Biophysical Chemistry
Biology JHU
A superresolution study of the novel role of DNA replication in establishing asymmetric epigenetic information
Zakaria, Sammy
   Cynthia Argani
   Robert Ehsanipoor
   Jamie Murphy
Obstetrics and Gynecology
Obstetrics and Gynecology, Maternal-Fetal Med
Anesthesia & Critical Care Medicine
The evaluation of right sided heart pathology and right ventricular systolic pressure in pre-eclamptic patients with severe features
Zhang, Jin
   Jie Xiao
Pharmacology and Molecular Sciences
Biophysics and Biophysical Chemistry
Superresolution imaging of protein-protein interactions in mammalian cells

To school of medicine faculty, staff and postdocs

Dear Colleagues:

The Johns Hopkins University School of Medicine announces the inaugural Discovery Fund request for applications:

Synergy Award Announcement
This announcement seeks proposals for innovative research projects led by faculty of the Johns Hopkins University School of Medicine (SOM). The expectation is that these awards will spark new, synergistic interactions between investigators and potentiate scientific achievements of the highest quality and impact. These awards are not intended to support already established projects or minimal extensions of ongoing research programs. Applications are solicited from the entire spectrum of disciplines at the SOM, from basic to clinical, and from all levels of academic faculty. Collaborations across all Johns Hopkins entities are eligible for consideration, but proposals must include a SOM faculty member as principal investigator or co-principal investigator.

Synergy Awards will consist of up to $100,000, with an award term of one year. Applicants must describe a credible plan that they will make substantial progress with one year of funding. Carryover of funds to a second year will be considered with justification under special circumstances. Successful applicants may re-apply for an additional year of funding in response to a future Discovery Fund RFA.

Application Deadline: May 1, 2014
Awards will be announced in mid-June for funding beginning July 1. It is expected that up to 10 Synergy Awards will be made this cycle. Additional Discovery Fund RFAs will be issued as funds become available.

Applications will consist of:

1. A research proposal, which should include four sections that succinctly describe the:
A) innovative hypothesis to be tested or goal to be achieved;
B) nature of the collaboration that enables the proposed work;
C) approach to be pursued during the year of funding; and
D) expected scientific impact of the proposed studies beyond the initial funded phase, including what future work would be enabled.
The research proposal section can be no more than four pages, not including any references. Shorter applications are encouraged. Since Synergy Awards are intended for new collaborative projects, no preliminary data are required.

2. A minimal budget description that describes how the funding will be allocated to each investigator in the collaboration and how it will be apportioned for any personnel, supplies and equipment. Any budget amount up to $100,000 can be proposed. Faculty salary and equipment costs can be included or excluded as desired. No indirect costs should be included in the budget.

3. An NIH-style biosketch for all investigators, without the personal statement, that includes all current and pending support from all sponsored and nonsponsored sources. Each biosketch is limited to four pages.

4. Up to five key words to aid in reviewer assignment.

Applications will be submitted through: (sorry, deadline has passed.)

Administrative questions about the application process can be best addressed by contacting Jolene Patey (, 443-287-0246). JHM Research Council members Joel Pomerantz ( and Kathleen Burns ( are available for scientific questions. The review process will stress the innovation of the project, its potential long-term impact and the synergy expected to result from the collaboration. Collaborators who have worked and published together in the past are not specifically excluded, but the project itself must be both highly innovative and as yet unfunded. Successful awardees may consult with the vice dean’s office for assistance if any administrative barriers to completing Synergy Award objectives are encountered.

Post–Award Requirements
Recipients will be expected to present their work as a team at a Discovery Fund Symposium, submit a six-month and final progress report, and report to the JHM Research Council on publications, reports of invention and external funding applications enabled by this award.

Daniel E. Ford, M.D., M.P.H.
David M. Levine Professor of Medicine and Psychiatry
Director, Institute for Clinical and Translational Research
Vice Dean for Clinical Investigation

Antony Rosen, M.B. Ch.B., B.Sc. (Hons)
Mary Betty Stevens Professor of Medicine
Professor of Cell Biology
Professor of Pathology
Director, Division of Rheumatology
Vice Dean for Research



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